Recently, there has been a surge in the interest in magic mushrooms for their potential role in managing various mental health disorders, particularly depression. One increasingly popular practice involves the regular intake of approximately 25 mg of the active ingredient, available for purchase from a mushroom dispensary. This dosage seems to hold promise in providing relief and may complement conventional depression treatments.
A study by a group of academics indicates that psilocybin, the active compound in magic mushrooms, has demonstrated promising results in the treatment of depression.
Main Points:
- Psilocybin may lead to a reduction in depression symptoms in as short as eight days.
- The side effects of psilocybin are typically manageable and usually range from mild to moderate.
- A dosage of 25mg of psilocybin may bring about changes in perception, mood shifts, increased creativity, and a feeling of unity.

One Dose Could Be Sufficient
A recent investigation applied a rigorous method, employing a randomized, multi-blinded approach to compare a single dose of psilocybin with an active placebo (niacin). The study examined the onset, duration of benefits, and safety profile of psilocybin over six weeks.
The Study Participants
The study targeted individuals aged 21 to 65 who met the Major Depressive Disorder (MDD) criteria as defined in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) and were undergoing a depressive episode lasting at least 60 days at the time.
The Procedure
Participants were administered either a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. The niacin served as an active placebo, causing an immediate physical response (flushing) to maintain the integrity of the blind study.
Both the psilocybin and niacin placebo were given following a standard “set and setting” protocol. The preparatory sessions, led by two facilitators, lasted between 6 and
The dosing session lasted between 7 and 10 hours in a serene environment. Four hours after receiving the dose, participants were invited to introspect on their experiences.
Insights from the Study
Just eight days after psilocybin was administered, a noticeable decrease in depression symptoms was observed. This positive effect persisted throughout the following six-week period, showing increased response and remission rates according to the Montgomery-Asberg Depression Rating Scale (MADRS). These results are more promising than those of other psilocybin studies in relation to Treatment-Resistant Depression.
Psilocybin outperformed niacin in improving psychosocial functioning. Using psilocybin showed promise in various aspects, including reducing the overall severity of illness, lowering anxiety, reducing self-reported depressive symptoms, and improving the quality of life.
Most participants tolerated the substance well, with only minor to moderate side effects primarily occurring after the first dose. However, compared to niacin, psilocybin treatment presented more frequent and severe side effects, which is consistent with our existing understanding of its effects.
The researchers emphasized that substances like psilocybin could trigger side effects that conventional rating scales may not always identify or could reveal previously unrecognised psychiatric disorders, even as they effectively treat specific symptoms.
What does a 25-mg Dose Signify?
A standard psychedelic dose usually consists of 15 to 25 milligrams of psilocybin (equivalent to 1.5 to 2.5 grams of dried mushrooms). This is the typical dosage for those seeking the full psychedelic effects of magic mushrooms.
This dosage can result in changes in perception, mood fluctuations, enhanced creativity, and a feeling of unity with the environment. Though mild visual effects may occur, intense hallucinations are rare. It’s like entering a vibrant dream world where reality fuses with a captivating mix of visual and auditory sensations.
The euphoric feelings often express themselves through dance, gentle movements, or pure surrender to the psychedelic rhythm. The experience generally lasts between 4 to 8 hours. At this level, visual distortions become more pronounced. Patterns appear to move and morph, and your surroundings seem to pulsate with energy.
While this dosage can be controlled, it demands a safe environment and a positive mindset. It offers an adventure filled with wonder and awe, inspiring you to delve into the realms of consciousness. with measured optimism.
- Notable enhancement in color perception.
- Visual distortions like seeing objects “breathe” or shift.
- Synesthesia experiences, such as “seeing sounds” or “hearing colours”.
- Deep appreciation for music.
- Outbursts of laughter.
- Altered touch sensations.
- Engagement in self-reflection.
- Feeling euphoric.
- Altered perception of time.
- Increased heart rate and blood pressure.
Available Products at Magic Mushroom Stores
Magic mushroom retailers offer an assortment of products laced with psilocybin. The offerings vary from dried mushrooms, to edibles, capsules, and beverages, with dried mushrooms being particularly sought-after.
Health Canada recognizes over 200 types of magic mushrooms, with Psilocybe cubensis being a commonly sold variety. Similar to cannabis dispensaries, this strain is available in numerous varieties, providing customers with a broad selection.
Further Shroom Products:
Edibles | Gummies and chocolates infused with psilocybin, with clear dosage instructions provided by the manufacturers. |
Capsules | Tasteless capsules that can be easily integrated into your wellness routine. They contain only minor amounts for a subtle enhancement. |
Beverages | Like edibles, but in drinkable form. They come as chocolate, coffee, or tea. |
Determining Your Dose at Magic Mushroom Dispensaries
Even though magic mushrooms aren’t a typical treatment for depression, Canada has taken a progressive step by allowing the testing and medical usage of psilocybin, a Schedule I substance under the Controlled Drugs and Substances Act, for specific patients battling severe major depressive disorder. This action could potentially help tens of thousands
For those grappling with anxiety and depression, clinical trials offer a venue to explore alternative treatment options.
Commonly Asked Questions
Can psilocybin be purchased from a medicinal mushroom dispensary?
Medicinal mushroom dispensaries generally carry products like Reishi, Turkey Tail, and Lion’s Mane. If you’re curious about the realm of mushrooms, an online magic mushroom dispensary could serve as your gateway. These dispensaries offer an array of mushroom products, encompassing dried mushrooms and other psychedelic substances.
Is a 25 mg dose effective for depression treatment?
Research into various psilocybin dosages for depression therapy is ongoing. Some studies have concentrated on lower dosages, while others have examined higher psilocybin levels. One approach could be to begin with a microdose and gradually amplify the dosage.
Can shrooms be purchased in Toronto?
Online mushroom vendors offer the convenience of making purchases from anywhere in Canada. Regardless of your province or city, these online platforms promise delivery to your location.
What is the least expensive product in an online mushroom store?
Dried mushrooms are typically the first choice for customers given the wide range of quantities offered. The price can fluctuate depending on whether you require a small quantity like 1 gram or intend to purchase in bulk. While edibles and other products have reasonable prices, they might not be as economically efficient as dried mushrooms.
Can a single shrooms dose help alleviate depression?
Some studies indicate that one-time usage can potentially lessen depression symptoms. However, it’s important to remember that the subjects of these studies also engaged in talk therapy alongside the treatment. The combination of psychedelic therapy and therapeutic discussions seems to yield the best results.
About the Author
The authorship of this article includes Charles L. Raison et al.; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito
Also contributing to this work are Richard J. Stevenson, Rebecca Smausz, Joanna Neill, and John Gigg.
Affiliated Organizations:
- The Usona Institute based in Fitchburg, Wisconsin
- SUNY Downstate Medical Center in Brooklyn, New York
- Neurogenesis Clinics, also in Brooklyn, New York
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- The Center for Psychedelic and Consciousness Research at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- The Department of Neuroscience at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine, Baltimore, USA
- The Department of Cognitive Science at Macquarie University in Sydney, Australia
- The Department of Psychology at Macquarie University in Sydney, Australia
- The Division of Neuroscience and Experimental Psychology in the Faculty of Biology, Medicine and Health at The University of Manchester, Manchester, UK
- The Division of Pharmacy and Optometry in the Faculty of Biology, Medicine and Health at The University of Manchester, Manchester, UK
- The Medical Psychedelics Working Group, under the umbrella of Drug Science, UK